Epigenetic basis of complex traits

We have a long-standing interest in exploring how epigenetic variation contributes to the heritability of complex traits. Currently, we are investigating the epigenetic basis of heterosis. It is well known that hybrid genomes undergo substantial functional remodeling at the transcriptional and epigenetic level. Our goal is to predict this remodeling from the epigenetic profiles of the parents, and to assess if/how it relates to phenotypic heterosis. 

Key paper:  

Cortijo et al. (2014) Mapping the epigenetic basis of complex traits. Science [Abstract]